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Researchers have speculated that the accumulation of p62 and ubiquitinated proteins observed in the lung tissues of patients with severe COPD-emphysema suggests an insufficient autophagic clearance is involved in the pathogenesis of COPD (Tran et al., 2015)

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Interestingly, HBE cells from smokers exhibited higher nuclear translocation of AIF ( p = 0.006) and EndoG ( p = 0.032) than cells from non-smokers (Fig

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